abstract：BACKGROUND/AIM:Curcumin is a promising nutraceutical for chemoprevention of head and neck squamous cell carcinoma (HNSCC). Capsular formulations of curcumin demonstrate low systemic bioavailability. We aimed to determine if curcumin levels were higher in healthy volunteers and cancer patients with microgranular curcumi...

journal_title：Anticancer research

authors： Latimer B,Ekshyyan O,Nathan N,Moore-Medlin T,Rong X,Ma X,Khandelwal A,Christy HT,Abreo F,McClure G,Vanchiere JA,Caldito G,Dugas T,McMartin K,Lian T,Mehta V,Nathan CA

更新日期：2015-12-01 00:00:00

abstract：:Cytotoxic efficacy of anticancer drugs has been widely studied with monolayer-cultured cancer cells. However, the drug efficacy under two-dimensional (2D) culture conditions usually differs from that of three-dimensional (3D) culture conditions. In the present study, an in vitro tumor tissue model was constructed by s...

journal_title：Anticancer research

authors： Iwase Y,Nakayama M,Yamato M,Okano T

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The present study investigated the mechanism underlying the apoptosis of MKN28 human gastric cancer cells induced by the phosphatidylinositol (PI) derivative 1,2-O-bis-[8-{2-(2-pentyl-cyclopropylmethyl)-cyclopropyl}-octanoyl]-sn-glycero-3-phosphatidyl-D-1-inositol (diDCP-LA-D-PI) and its enantiomer diDCP-LA-...

journal_title：Anticancer research

authors： Ohyama M,Tsuchiya A,Kaku Y,Kanno T,Shimizu T,Tanaka A,Nishizaki T

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND/AIM:Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a rare autosomal dominant disorder characterized by fumarate hydratase (FH) gene mutation. It is associated with the development of very aggressive kidney tumors, characterized by early onset and high metastatic potential, and has no effective...

journal_title：Anticancer research

authors： Perrier-Trudova V,Huimin BW,Kongpetch S,Huang D,Ong P,Le Formal A,Poon SL,Siew EY,Myint SS,Gad S,Gardie B,Couvé S,Foong YM,Choudhury Y,Poh J,Ong CK,Toh CK,Ooi A,Richard S,Tan MH,Teh BT

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The prognosis for advanced gastric cancer with paraaortic lymph node (PALN) metastasis is very poor even after a curative resection. In the present study, induction chemotherapy followed by curative surgery was performed for advanced gastric cancer with PALN metastasis. PATIENTS AND METHODS:Twenty patients ...

journal_title：Anticancer research

authors： Fujiwara Y,Omori T,Demura K,Miyata H,Sugimura K,Ohue M,Kobayashi S,Takahashi H,Doki Y,Yano M

更新日期：2015-12-01 00:00:00

abstract：AIM:Aim of the study was to evaluate feasibility and toxicities of exclusive radiosurgery using tomotherapy in patients with brain oligo-metastases. PATIENTS AND METHODS:Between 2008 and 2013 68 patients underwent stereotactic radiosurgery (SRS). Mean patient age was 63 years. Brain was the only site involved in 32 pa...

journal_title：Anticancer research

authors： Bruni A,Gaito S,Ciarmatori A,Lanfranchi B,Mazzeo E,Maffei N,Giacobazzi P,Turco E,Guidi G,Bertoni F

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:The aim of the present study was to evaluate the effectiveness and safety of hepatic re-resection for breast cancer liver metastases. PATIENTS AND METHODS:Between January 2004 and December 2014 seven patients were submitted to liver re-resection for breast cancer liver metastases at our Center. The main inc...

journal_title：Anticancer research

authors： BacalbaȘa N,Balescu I,Dima S,Popescu I

更新日期：2015-12-01 00:00:00

abstract：AIM:To evaluate factors associated with the selection of first-line bevacizumab plus chemotherapy and clinical response in HER2-negative metastatic breast cancer (MBC) in clinical practice in Spain. PATIENTS AND METHODS:All consecutive adult female patients with HER2-negative MBC who had received first-line bevacizuma...

journal_title：Anticancer research

authors： Manso L,Palomo AG,Pérez Carrión R,Cassinello J,Gallegos Sancho I,Chacón López-Muñiz I,Olier C,Fernández-Aramburo A,Llorca C,González X,Llorente R,Torregrosa D,Álvarez I,Gálve E,Bueno C,Garau I,García MJ,González-Santiag

更新日期：2015-12-01 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) ranks as a leading cause of cancer-related death globally. Brain metastases are a frequent complication of NSCLC, with 25-40% of patients developing brain metastases during the course of the disease, often within the first 2 years after diagnosis of the primary tumor. Improvements in...

journal_title：Anticancer research

authors： Dempke WC,Edvardsen K,Lu S,Reinmuth N,Reck M,Inoue A

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Fibroblast growth factor receptors are expressed in diverse cell types. They play a critical role in tumor development. Their activation promotes cell-cycle progression, angiogenesis, and cell survival by induction/suppression of the expression of proteins involved. MATERIALS AND METHODS:Non-small cell lung...

journal_title：Anticancer research

authors： Göke A,Göke R,Ofner A,Herbst A,Lankat-Buttgereit B

更新日期：2015-11-01 00:00:00

abstract：AIM:Mesenchymal-epithelial transition factor (MET), a receptor tyrosine kinase, is expressed in head and neck squamous cell carcinomas (HNSCC) and is involved in tumor progression and associated with poor prognosis. MET can be inhibited by crizotinib, a potent ATP-competitive kinase inhibitor. We examined the effects o...

journal_title：Anticancer research

authors： Baschnagel AM,Galoforo S,Thibodeau BJ,Ahmed S,Nirmal S,Akervall J,Wilson GD

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Active hexose-correlated compound (AHCC) is an extract of a basidiomycete mushroom that enhances the therapeutic effects and reduces the side-effects of chemotherapy. Our previous studies demonstrated that heat-shock protein 27 (HSP27) was involved in gemcitabine-resistance of pancreatic cancer cells and it ...

journal_title：Anticancer research

authors： Tokunaga M,Baron B,Kitagawa T,Tokuda K,Kuramitsu Y

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND/AIM:The impact of testosterone or obesity on the pathological grade of prostate cancer remains controversial. Therefore, in this study, we investigated the relationship of serum testosterone and body mass index (BMI) to Gleason score at biopsy. PATIENTS AND METHODS:This study included 128 Japanese patients ...

journal_title：Anticancer research

authors： Shiota M,Takeuchi A,Sugimoto M,Dejima T,Kashiwagi E,Kiyoshima K,Inokuchi J,Tatsugami K,Yokomizo A

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND/AIM:It is generally believed that the plasma concentration of 5-fluorouracil (5-FU) is constant when 5-FU is continually administered for chemotherapy. The aim of the present study was to verify whether this is true. PATIENTS AND METHODS:Nine patients with colorectal cancer were enrolled in this study. All ...

journal_title：Anticancer research

authors： Matsumoto H,Okumura H,Murakami H,Kubota H,Higashida M,Tsuruta A,Tohyama K,Hirai T

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The safety and efficacy of second-line chemotherapy for treating patients with small cell lung cancer (SCLC) and interstitial lung disease (ILD) have not been elucidated to date. PATIENTS AND METHODS:Between January 2005 and September 2013, we analyzed 23 patients with SCLC and ILD who received second-line ...

journal_title：Anticancer research

authors： Fujimoto D,Shimizu R,Kato R,Sato Y,Kogo M,Ito J,Teraoka S,Otoshi T,Nagata K,Nakagawa A,Otsuka K,Katakami N,Tomii K

更新日期：2015-11-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) represent the most common mesenchymal tumor entity of the gastrointestinal tract. In fewer than 5% of cases, primary GISTs are located in the duodenum. Surgery represents the treatment of choice for localized tumor disease and remains challenging in GISTs located at the duodenum...

journal_title：Anticancer research

authors： Mrak K,Liegl-Atzwanger B,Haybaeck J,Petritsch W,Mischinger HJ,Kornprat P

更新日期：2015-11-01 00:00:00

abstract：AIM:The purpose of the present study was to determine whether genes involved in the organization of the hematopoietic niche were dysregulated in patients with primary myelofibrosis (MF) treated with lenalidomide. MATERIALS AND METHODS:We used reverse-transcription quantitative polymerase chain reaction to study the ex...

journal_title：Anticancer research

authors： Livun A,Newberry KJ,Manshouri T,Kusec R,Verstovsek S

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Sixteen 3-styryl-2H-chromenes were subjected to quantitative structure-activity relationship analysis based on their cytotoxicity, tumor selectivity and anti-HIV activity, in order to find their new biological activities. MATERIALS AND METHODS:Cytotoxicity against four human oral squamous cell carcinoma (OS...

journal_title：Anticancer research

authors： Uesawa Y,Sakagami H,Ishihara M,Kagaya H,Kanamoto T,Terakubo S,Nakashima H,Yahagi H,Takao K,Sugita Y

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND/AIM:Peripheral neurotoxicity is a dose-limiting factor of many chemotherapeutic agents, including cisplatin. Mesenchymal stem cells are promising for the treatment of several neurological disorders, and our aim was to verify the neuroprotective potential of human mesenchymal stem cells (hMSCs) on dorsal root...

journal_title：Anticancer research

authors： Scuteri A,Ravasi M,Monfrini M,Milano A,D'Amico G,Miloso M,Tredici G

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:While procarbazine with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (PC) added to vincristine (PCV) was proven beneficial in the treatment of co-deleted anaplastic oligodendroglioma (AO), the question of whether PC alone is sufficient is important, as vincristine adds toxicity with uncertain benefit. This r...

journal_title：Anticancer research

authors： Webre C,Shonka N,Smith L,Liu D,De Groot J

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:A woman, mother of one at the age of 19 years, was diagnosed with mammary adenocarcinoma in the right breast in 1985 at the age of 37 years. The patient underwent surgery (quadrantectomy), lymphadenectomy and radiotherapy. In 1999, an adenocarcinoma was diagnosed in the left breast, followed by adequate rese...

journal_title：Anticancer research

authors： Branca JJ,Pacini S,Ruggiero M

更新日期：2015-10-01 00:00:00

abstract：AIM:Adjuvant treatment is still controversially discussed for elderly colon cancer (CC) patients. Our aim was to investigate the benefit of adjuvant treatment for younger (<70 years) and elderly (≥70 years) patients. PATIENTS AND METHODS:The long-term outcome of patients (n=855) enrolled in a randomized controlled tri...

journal_title：Anticancer research

authors： Mayer B,Sander S,Paschke S,Henne-Bruns D,Link KH,Kornmann M,Study Group Oncology of Gastrointestinal Tumors (FOGT).

更新日期：2015-10-01 00:00:00

abstract：AIM:To identify tissue biomarkers that are predictive of the therapeutic effect of sunitinib in treatment of metastatic clear cell renal cell carcinoma (mCRCC). MATERIALS AND METHODS:Our study included 39 patients with mCRCC treated with sunitinib. Patients were stratified into two groups based on their response to su...

journal_title：Anticancer research

authors： Trávníček I,Branžovský J,Kalusová K,Hes O,Holubec L,Pele KB,Ürge T,Hora M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND/AIM:DNA methylation is a common epigenetic change in cancer. However, microRNA (miRNA) regulation by epigenetic alteration, especially CpG island hypermethylation, remains poorly understood in esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS:miRNAs which were up-regulated after de-methylatio...

journal_title：Anticancer research

authors： Harada K,Baba Y,Ishimoto T,Kosumi K,Tokunaga R,Izumi D,Ohuchi M,Nakamura K,Kiyozumi Y,Kurashige J,Iwagami S,Miyamoto Y,Sakamoto Y,Yoshida N,Oki E,Watanabe M,Baba H

更新日期：2015-09-01 00:00:00

abstract：UNLABELLED:Synthetic cannabinoid WIN55,212-2 (WIN) has shown a promise as an anticancer agent but causes psychoactive side-effects. In the present study, nano-micelles of styrene maleic acid (SMA)-conjugated WIN were synthesized to reduce side-effects and increase drug efficacy. SMA-WIN micelles were characterised and ...

journal_title：Anticancer research

authors： Xian S,Parayath NN,Nehoff H,Giles NM,Greish K

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND/AIM:4-methylumbelliferone (4-MU) has received considerable attention due to its potential for cancer treatment since it inhibits cell proliferation, migration and invasion. An increasing body of evidence suggests that extracellular matrix (e.g. hyaluronan) and nutrients (e.g. glucose) in the tumor microenvir...

journal_title：Anticancer research

authors： Wang R,Zhou W,Wang J,Liu Y,Chen Y,Jiang S,Luo X,Stupack DG,Luo N

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND/AIM:The Glasgow Prognostic Score (GPS), an inflammation-based prognostic score, has been shown to predict the clinical outcomes of a variety of cancer types. The aim of this study was to determine whether the GPS predicts clinical outcomes of patients with pancreatic cancer treated with adjuvant chemotherapy...

journal_title：Anticancer research

authors： Morinaga S,Murakawa M,Katayama Y,Yamaoku K,Aoyama T,Kanazawa A,Higuchi A,Shiozawa M,Kobayashi S,Ueno M,Morimoto M

更新日期：2015-09-01 00:00:00

abstract：:Iceland has a total population of 300,000 inhabitants. All patients consulting for symptoms of the lower digestive tract during a four-year period (2003-2006) were subjected to a colonoscopic examination; all polyps were endoscopically removed. Out of the total 3,037 colorectal adenomas (CRAs), 308 (10.2%) were tradit...

journal_title：Anticancer research

authors： Rubio CA,Jónasson JG

更新日期：2015-09-01 00:00:00

abstract：AIM:We analyzed pentafecta outcomes [complication-free, continence, potency, negative surgical margins (NSM)], biochemical recurrence (BCR)-free] of 230 patients undergoing robotic-assisted radical prostatectomy (RARP) with bilateral neurovascular (NVB) preservation. PATIENTS AND METHODS:Patient outcomes (group I, cas...

journal_title：Anticancer research

authors： Ou YC,Yang CK,Kang HM,Chang KS,Wang J,Hung SW,Tung MC,Tewari AK,Patel VR

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND/AIM:Patients with obstructive jaundice due to cancer of the pancreatic head often undergo preoperative endoscopic biliary drainage (EBD). The aim of the study was to evaluate the long-term impact of preoperative EBD following pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma. PATIENTS AND ME...

journal_title：Anticancer research

authors： Furukawa K,Shiba H,Shirai Y,Horiuchi T,Iwase R,Haruki K,Fujiwara Y,Misawa T,Yanaga K

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND/AIM:In order to develop an efficient drug-delivery system (DDS), a lipopeptide-loaded liposome that functions as a platform for the transpeptidase reaction mediated by sortase A (SrtA) was constructed and its stability, as well as cell-specific targeting were evaluated in the present study. MATERIALS AND ME...

journal_title：Anticancer research

authors： Tabata A,Ohkubo Y,Anyoji N,Hojo K,Tomoyasu T,Tatematsu Y,Ohkura K,Nagamune H

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND/AIM:Neuroblastoma is a pediatric solid tumor refractory to eradication by chemotherapy. To determine whether Aloe vera (AV), a pontial anticancer reagent, could be useful in neuroblastoma therapy, we investigated the anti-proliferative effects of an AV protein extract. MATERIALS AND METHODS:Human neuroblast...

journal_title：Anticancer research

authors： Yonehara A,Tanaka Y,Kulkeaw K,Era T,Nakanishi Y,Sugiyama D

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND/AIM:Sarcoma of the oral cavity is rare accounting for around 1% of all malignant oral tumors. The purpose of this study was to find important prognostic factors for patients with oral sarcoma. PATIENTS AND METHODS:The study included 1,643 patients examined from April 1980 to March 2010 at the Departments of...

journal_title：Anticancer research

authors： Sumida T,Otawa N,Kamata YU,Yamada T,Uchida K,Nakano H,Hamakawa H,Yamamoto T,Ueyama Y,Mori Y

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Expression of novel stem cell-associated marker human embryonic stem cell 77 (HES77) was studied in rectal neuroendocrine tumors (NETs), which comprise 10 to 15% of gastroenteropancreatic NETs, some with metastatic potential. MATERIALS AND METHODS:WHO 2010 classification was applied, and immunohistochemical...

journal_title：Anticancer research

authors： Jernman J,Hagström J,Mäenpää H,Välimäki MJ,Haapasalo H,Nilsson O,Fermér C,Haglund C,Arola J

更新日期：2015-07-01 00:00:00

abstract：:Elevated levels of hypoxia inducible factor-1 (HIF1) are linked to tumor metastasis, angiogenesis, poor patient prognosis and response to chemotherapy. HIF1α is a master regulator of the hypoxic response, including in cancer cells, through transcriptional activation of several target genes. Previously, we identified c...

journal_title：Anticancer research

authors： Masoud GN,Wang J,Chen J,Miller D,Li W

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND/AIM:Primary brain tumors are unique tumors due to their different pathobiological behavior, while they rarely metastasize outside the central nervous system. Regarding the oncogenesis of primary brain tumors, it was shown that changes in functions of p16 and mouse double minute 2 homolog (MDM2) are related t...

journal_title：Anticancer research

authors： Kafadar A,Küçükhüseyin Ö,Turan S,Yenilmez EN,Tunoglu S,Zeybek U,Kaynar MY,Kemerdere R,Yaylim I

更新日期：2015-07-01 00:00:00

abstract：AIM:Human papillomavirus (HPV) is a risk factor for oropharyngeal squamous cell carcinoma (OPSCC), with an increasing incidence. The present study aimed to determine the changing incidence of HPV in patients with OPSCC in the period 1980-2009 and its influence on survival. PATIENTS AND METHODS:We randomly sampled 158 ...

journal_title：Anticancer research

authors： Henneman R,Van Monsjou HS,Verhagen CV,Van Velthuysen ML,Ter Haar NT,Osse EM,Lopez-Yurda MI,Balm AJ,Van Den Brekel MW

更新日期：2015-07-01 00:00:00

abstract：AIM:The present study aimed to examine the survival benefit of adjuvant chemotherapy for the patients with stage IB gastric cancer according to the second English edition of the Japanese Classification of Gastric Carcinoma (2nd JCGC). PATIENTS AND METHODS:In total, 201 consecutive patients who underwent curative surge...

journal_title：Anticancer research

authors： Toyokawa T,Ohira M,Sakurai K,Kubo N,Tanaka H,Muguruma K,Hirakawa K

更新日期：2015-07-01 00:00:00

abstract：AIM:To evaluate the efficacy of prophylactic radiotherapy at intervention sites in patients with malignant pleural mesothelioma (MPM). PATIENTS AND METHODS:From 05/2010 to 12/2014, 53 patients with histologically confirmed MPM were treated in order to prevent interventional site metastases. Irradiation was carried out...

journal_title：Anticancer research

authors： Janssen S,Schönhofer B,Rades D

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Anti-epidermal growth factor receptor (EGFR) monoclonal antibodies benefit patients with wild-type KRAS exon 2 metastatic colorectal cancer (mCRC). However, their effect in KRAS-mutant mCRC remains unclear. PATIENTS AND METHODS:This was a retrospective study enrolling 163 patients with unresectable KRAS-mut...

journal_title：Anticancer research

authors： Liang YH,Lin YL,Liau JY,Tsai JH,Liang JT,Lin BR,Hung JS,Tseng LH,Lin LI,Chang YL,Cheng AL,Yeh KH

更新日期：2015-07-01 00:00:00